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Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little body johnson available for drug body johnson and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options.

Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health agencies, drug developers, and funding agencies.

Given the development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks body johnson to emerging viruses. In the studies described here, a library of 290 compounds was screened for antiviral activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe body johnson respiratory syndrome body johnson (SARS-CoV).

Selection of compounds for inclusion in the library was dependent on current or previous FDA approval or advanced clinical development.

Some drugs that had a well-defined cellular pathway as target were included. In total, 27 compounds with activity against both MERS-CoV and SARS-CoV were identified. The compounds belong to 13 different classes of pharmaceuticals, including inhibitors of estrogen receptors used for cancer treatment and inhibitors of dopamine receptor used as antipsychotics. The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies.

Khalid M, Al Rabiah F, Mobeireek A, Butt TS, Mutairy EA. Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized transmissible body johnson infection with high virulence and case fatality rates for which there is no currently defined primary treatment body johnson prophylaxis.

Saudi Arabia has the largest reported number of cases so far. Like severe acute respiratory syndrome (SARS), MERS is caused by a coronavirus. In this report, we describe for the first time use of this combination as a primary treatment for a body johnson with MERS-CoV infection and as prophylaxis for his spouse and body johnson its possible role.

Falzarano D, de Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, msx1 al. The rhesus macaque is the only known model organism for MERS-CoV infection, developing an acute localized to widespread pneumonia with transient clinical disease that recapitulates mild to moderate human MERS-CoV cases. In contrast to untreated, infected macaques, treated animals did not develop breathing abnormalities and showed no or very mild radiographic evidence of pneumonia.

Moreover, treated animals showed lower levels of systemic (serum) and local (lung) body johnson markers, in addition to fewer viral genome copies, distinct gene expression and less drawing histopathological changes in the lungs.

Unravelling the convoluted biological roles of type I interferons (IFN-Is) in infection and immunity: a way forwad for the therapeutics and vaccine design. Wijesundara DK, Xi Y, Ranasinghe C. It has been well-established that type I interferons (IFN-Is) have pleiotropic effects and play an early central role in the control body johnson many acute viral infections.

However, their pleiotropic effects are not always beneficial to the body johnson and in fact several reports suggest body johnson the induction of IFN-Is exacerbate disease outcomes against some bacterial and chronic viral body johnson. In this brief review, we probe into this mystery and try to develop answers based on past and recent studies evaluating the roles of IFN-Is in infection body johnson immunity as body johnson is vital for developing effective IFN-Is based therapeutics and vaccines.

National Library of Medicine (US). Maryland: National Library of Medicine (US). Yale University Press Blog, 2020 Mar 12. Cuban Interferon Alpha 2b has proven effective for viruses with characteristics similar body johnson those of COVID-19. Cuban biotech specialist Dr.

To date, there is still no specific vaccine. Newsweek, 2020 Mar 24. Cuban Medication Interferon alpha Selected Among Drugs to Combat Coronavirus. El hecho y la noticia del antiviral body johnson en China. La Jornada, 2020 Feb 20. How Cuba is leading the world in the fight against coronavirus. MPN News, 2020 Mar 16. As Cuba sends doctors around the world to help fight coronavirus, a Cuban antiviral drug, Interferon Alpha 2b, is helping countries like China stem the tide of the body johnson. Promising Treatment for New Human Coronavirus.

MEDICC Review online (ISSN 1527-3172) is body johnson open access body johnson, allowing readers to freely access, copy, use, distribute, transmit and display its contents, and to make and distribute derivative works, subject to proper attribution of body johnson (including the original copyright notice).

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