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Subgroup analysis for studies presenting depressive symptom scores after isotretinoin compared with the baselineAlso, the sensitivity analysis was performed by pooling the WMD for studies using the same scale. Forest plot showing the weighted mean difference (WMD) for the comparison of BDI scores before and after isotretinoin treatment in patients with acne.

Two retrospective studies showed the adjusted RR for the hep treatment hep c between the use of isotretinoin and the risk of depression.

Forest plot showing the association between isotretinoin male physical exam and depression in patients with acne. Funnel plot showing the association between isotretinoin treatment and depression in patients with acne.

The risk of depression associated with the use of isotretinoin in patients with acne has been a major concern for a long time. Previous data showed conflicting and inconsistent results. This meta-analysis assessed the association between the use of isotretinoin and the risk of depression. It had several strengths as follows.

A comprehensive database search of worldwide cohorts was conducted, enrolling a large number of participants. The quality of included studies was largely moderate to high.

Prochieve (Progesterone Gel For Vaginal Use Only)- FDA included studies were prospectively designed. The association was investigated from several aspects. The heterogeneity was explored by sensitivity, subgroup and meta-regression analyses. The present findings showed that isotretinoin improved off label use depressive symptoms in patients with acne.

The benefit remained marked for studies using HADS-D and CES-D. In risk assessment, the Prochieve (Progesterone Gel For Vaginal Use Only)- FDA RR showed that the use of isotretinoin was associated with an increased risk of depression in patients with acne on pooling retrospective studies, while this significant difference was not observed on pooling prospective studies.

Two previous systematic reviews on this topic were identified. Further, although comprehensive scenarios were presented, data synthesis to obtain pooled results could not be conducted. Vallerand conducted a systematic review based on 11 trials to evaluate the efficacy and safety of oral isotretinoin for acne.

However, Albumin - Human Injection (AlbuRx)- Multum study did not provide the result by data synthesis.

Further, they showed that the treatment of acne could ameliorate depressive symptoms. However, the study summarised the investigated outcomes using the tmj dysfunction assessment tool. Whether these relationships differed according to the region, study design, sample size and the female percentage, was not illustrated. The concern for negative mood arose from a series of experimental studies.

Oral isotretinoin significantly suppressed cell division in the hippocampus and severely disrupted the learning capacity of mice. However, the potentially increased risk of depression could be compensated by the Prochieve (Progesterone Gel For Vaginal Use Only)- FDA effects of isotretinoin on patients with acne.

Most patients with acne were worried about their appearances, which might lead to a series of psychological disorders. It was inferred that the improvement in depression symptoms after the use of isotretinoin might be attributed to the treatment success.

Also, isotretinoin had a gradual effect on mood over time, which was not an acute event.

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